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  - WN.COM - Science - 26/Jun 05:06

How Do Axolotls Know Which Tissue to Regenerate?

In the muddy waters of Mexican lakes, birds prey on axolotls by clamping their sharp teeth around the salamanders’ limbs and snapping them off. But, unlike humans who can’t regrow missing limbs, axolotls are masters of regeneration. The amputation site gradually grows a bud that eventually develops into a perfect replica of the original limb, complete with the thumb and pinky on the correct sides. How does the axolotl’s body know to regenerate a limb at the severed site and not a tail or another tissue? This is in part due to positional memory—the spatial identity assigned to adult cells during embryonic development—that cells carry and use to restore the correct organ after an injury.1 “How...

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