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  - WN.COM - Science - Hier 05:19

Genetic Variability Affects How Tumors Respond to Immunotherapy

From eye color to whether cilantro tastes like soap, genetic variability influences many factors in a person’s life. These inherited differences can also determine a person’s risk of developing a particular type of cancer and possibly even the response to certain kinds of cancer therapies. For example, while immune checkpoint inhibitors represent a huge advance in cancer treatment, they only succeed in a subset of patients.1 However, the precise role of genetics is difficult to study because a person’s immune system and the therapy itself also affect the tumor. Edison Liu turned to the genetically diverse Collaborative Cross mouse model to answer questions about the role of gene variation in...

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