Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage...
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From eye color to whether cilantro tastes like soap, genetic variability influences many factors in a person’s life. These inherited differences can also determine a person’s risk of developing a particular type of cancer and possibly even the response to certain kinds of cancer therapies. For example, while immune checkpoint inhibitors represent a huge advance in cancer treatment, they only succeed in a subset of patients.1 However, the precise role of genetics is difficult to study because a person’s immune system and the therapy itself also affect the tumor. Edison Liu turned to the genetically diverse Collaborative Cross mouse model to answer questions about the role of gene variation in...
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage...
Melanoma, one of the deadliest forms of skin cancer, affects an estimated 330,000 people worldwide each year and causes nearly 60,000 deaths...
Melanoma, one of the deadliest forms of skin cancer, affects an estimated 330,000 people worldwide each year and causes nearly 60,000 deaths...
A team of researchers at the UCLA Health Jonsson Comprehensive Cancer Center has identified a potential new strategy to prevent, and even reverse,...
FRIDAY, July 11, 2025 -- The introduction of immune checkpoint inhibitors (ICIs) was associated with a widening survival disparity between those with...
Researchers identify PPP2R1A gene mutations as a new marker linked to better immunotherapy response and survival in ovarian and other cancers.
Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy...
Advanced treatments, known as immunotherapies that activate T cells—our body's immune cells—to eliminate cancer cells, have shown limited efficacy...
Advanced treatments, known as immunotherapies that activate T cells—our body’s immune cells—to eliminate cancer cells, have shown limited...
Advanced treatments, known as immunotherapies that activate T cells—our body’s immune cells—to eliminate cancer cells, have shown limited...