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  - WN.COM - Science - 06/Aug 16:37

Low Brain Lithium Leads to Alzheimer’s Disease Pathology

In Alzheimer's disease, researchers have identified genetic variants and other risk factors related to diet, lifestyle, the environment, but metal levels in the brain also contribute to the condition.1 Imbalanced levels of iron, copper, and zinc can promote features of Alzheimer’s pathology such as amyloid-β (Aβ) aggregation, tau phosphorylation, and oxidative stress.2 However, there are other metals that contribute to brain function, and how these are affected or disrupted in Alzheimer’s disease is still largely unexplored. To tackle this metal mystery further, researchers from Harvard Medical School and Rush University Medical Center teamed up. When they...

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