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  - WN.COM - Science - Aujourd'hui 05:02

AI Tool Identifies Disease-Driving Promoter Mutations

Each cell in the body is like a miniscule bowl of genetic soup, holding RNA from thousands of genes. But unlike an actual bowl of soup, which can forgive a little too much or not enough of certain ingredients, deviations from normal levels of gene expression can have deleterious effects on cells. These gene expression changes can lead to diseases such as cancer, diabetes, autoimmunity, and cardiovascular disorders. Various DNA regulatory elements work together to ensure gene expression matches the cell’s needs, key among which is the gene promoter. Scientists have previously shown that promoters can drastically alter gene expression, suggesting that mutations in these non-coding regions of...

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