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Maroc Maroc - NEWS.MEDICAL.NET - A la Une - 10/Oct 04:31

Evolutionary mutation in cGAS enhances naked mole-rat DNA repair

The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an enzyme in the innate immune system that senses DNA to trigger immune responses – may enhance the animal's ability to repair aging-related genetic damage, whereas in other species, such as mice and humans, cGAS can suppress DNA repair.

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