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Maroc Maroc - WN.COM - Science - 06/Nov 22:25

Scientists Find Way to Make Lung Cancer Cells Self-Destruct

Small cell lung carcinoma, chromogranin immunostain. Credit: – CC BY-SA 2.0 via Wikimedia Commons. Researchers at NYU Langone Health said Wednesday that an experimental drug that blocks a key protein can trigger a form of self-destruction in lung cancer cells and dramatically slow tumor growth in mice, a finding published Nov. 5 in the journal Nature. The team reported that inhibiting ferroptosis suppressor protein 1, or FSP1, unleashes ferroptosis, a non-apoptotic cell-death process driven by iron-dependent lipid peroxidation, and reduced tumor growth by as much as 80% in mouse models of lung adenocarcinoma, the most common lung cancer among people who have never smoked. The study...

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