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Maroc Maroc - WN.COM - Science - 19/12/2025 08:17

A 3D Scaffold Helps Recreate the Human Bone Marrow Niche

The bone marrow serves as the main site of hematopoiesis in humans, giving rise to red and white blood cells. This space is highly organized into distinct regions, or niches, that perform different functions. One of these, the endosteal niche, lies closest to the bone and consists of bone-producing cells called osteoblasts, vascular cells, and hematopoietic stem cells. In mice, researchers have shown that this niche is often where blood disorders can form or where tumors can metastasize.1,2 However, the endosteal niche and its functions have not been well studied in humans. “One of the biggest challenges of modeling the bone marrow in vitro is trying to recreate this cellular complexity that...

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