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Maroc Maroc - WN.COM - Science - 09/Jan 19:16

Sweet Deception: How Mycobacteria Exploit Immune Receptors to Survive

Successful infection often depends on a pathogen’s ability to evade host immune cell detection through stealthy mechanisms. After a person inhales Mycobacterium tuberculosis (MTB) into their lungs, phagocytic cells such as macrophages engulf it. Although innate pattern recognition receptors (PRRs) on macrophages recognize the bacteria and activate intracellular immune responses, MTB can dodge these defenses to survive and facilitate the development of tuberculosis. The PRR dectin-1 recognizes β-glucan...

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